Arnold Schwarzenegger complained that Grace Jones was "too tough" during the filming of Conan the Destroyer That's what we like about this androgynous man killer. Arnold must have enjoyed her sexy ways, too, as she attended his wedding to Maria Shriver on Cape Cod with the only partner that could out-weird her, Andy Warhol. Grace studied theater at Syracuse University before becoming a successful model in Paris--her modeling agency thought her looks too "strong" for New York. Her peculiar and statuesque style made her a hot attraction in New York City's underground and nightlife scenes, and her sexually charged stage shows and songs like "I Need a Man" earned her the title "The Queen of Gay Discos. But men of all sexual perversions find something they can call their own in Grace.
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Mdm2 protein functions both as an E3 ubiquitin ligase that recognizes the N-terminal trans-activation domain TAD of the p53 tumor suppressor and as an inhibitor of p53 transcriptional activation. The murine double minute mdm2 oncogene , which codes for the Mdm2 protein, was originally cloned, along with two other genes mdm1 and mdm3 from the transformed mouse cell line 3T3-DM. Mdm2 overexpression, in cooperation with oncogenic Ras , promotes transformation of primary rodent fibroblasts, and mdm2 expression led to tumor formation in nude mice. The human homologue of this protein was later identified and is sometimes called Hdm2. Further supporting the role of mdm2 as an oncogene , several human tumor types have been shown to have increased levels of Mdm2, including soft tissue sarcomas and osteosarcomas as well as breast tumors. The MDM2 oncoprotein ubiquitinates and antagonizes p53 but may also carry out pindependent functions. MDM2 supports the Polycomb -mediated repression of lineage-specific genes, independent of p
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At the tender age of twenty Kelly Preston already measured a respectable , and her top-heavy talents only expanded way, way out! She took that fine figure on the road as an Elite Agency model, then turned to a role on the now-defunct soap opera Capitol before heading off to cinematic efforts like Christine , SpaceCamp , and Twins , which would prove to be her breakthrough role. She married noted Scientologist John Travolta and converted to the controversial faith, which fortunately does not forbid nudity, because she has a legacy of it onscreen.
The breast is one of two prominences located on the upper ventral region of the torso of primates. In females, it serves as the mammary gland , which produces and secretes milk to feed infants. At puberty , estrogens , in conjunction with growth hormone , cause breast development in female humans and to a much lesser extent in other primates. Breast development in other primate females generally only occurs with pregnancy.